The diagram below illustrates the pathways involved in cholesterol production. The process begins with acetyl-CoA, a two-carbon molecule sometimes referred to as the “building block of life.” Three acetyl-CoA molecules combine to form six-carbon hydroxymethyl glutaric acid (HMG). The step from HMG to mevalonate requires an enzyme, HMG-CoA reductase. Statin drugs work by inhibiting this [...]
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We will continue talking on the subject of how the statin drugs work. We already mentioned that most of its side effects are related with the effect of the drugs blocking the production of Co-Q10, which in term interfere with the production of ATP at the muscle level and other tissues. The November 2003 issue [...]
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